Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer therapy

Tumours switch to resist

Tumour cells can respond to targeted immune-cell therapies by losing proteins that mark them as being cancerous. Subverting this resistance mechanism may lead to more durable cancer-treatment strategies. See Letter p.412

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Escape by dedifferentiation.

Notes

  1. 1.

    *This article and the paper under discussion1 were published online on 10 October 2012.

References

  1. 1

    Landsberg, J. et al. Nature 490, 412–416 (2012).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Restifo, N. P., Dudley, M. E. & Rosenberg, S. A. Nature Rev. Immunol. 12, 269–281 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Rosenberg, S. A. et al. Clin. Cancer Res. 17, 4550–4557 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Morgan, R. A. et al. Science 314, 126–129 (2006).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Johnson, L. A. et al. Blood 114, 535–546 (2009).

    CAS  Article  Google Scholar 

  6. 6

    Robbins, P. F. et al. J. Clin. Oncol. 29, 917–924 (2011).

    Article  Google Scholar 

  7. 7

    Ferrone, S. & Marincola, F. M. Immunol. Today 16, 487–494 (1995).

    CAS  Article  Google Scholar 

  8. 8

    Ma, C. et al. Nature Med. 17, 738–743 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Antoni Ribas.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ribas, A., Tumeh, P. Tumours switch to resist. Nature 490, 347–348 (2012). https://doi.org/10.1038/nature11489

Download citation

Search

Quick links