Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MicroRNA-10b and breast cancer metastasis


Arising from: L. Ma, J. Teruya-Feldstein & R. A. Weinberg Nature 449, 682–688 (2007)10.1038/nature06174; Ma et al. reply

MicroRNAs regulate messenger RNA expression but are frequently dysregulated in tumours. Ma et al.1 report that overexpression of microRNA-10b (miR-10b) initiates invasion and metastasis in models of breast cancer and that its expression in primary breast carcinomas correlates with clinical progression. We tested this in patients with primary breast cancer, of whom 92 had nodal metastases at diagnosis and 127 were node-negative. We found no significant association between miR-10b levels and metastasis or prognosis. Although we concede that miR-10b may have a biological effect in a few cells at the growing edge of a tumour, we believe that it is unlikely to correlate in whole tumour samples with clinical progression.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: miR-10b is not significantly associated with metastasis.


  1. Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682–688 (2007)

    Article  ADS  CAS  Google Scholar 

  2. McShane, L. M. et al. REporting recommendations for tumour MARKer prognostic studies (REMARK). Br. J. Cancer 93, 387–391 (2005)

    Article  CAS  Google Scholar 

  3. Hudis, C. A. et al. Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: the STEEP system. J. Clin. Oncol. 25, 2127–2132 (2007)

    Article  Google Scholar 

  4. Tan, E. Y. et al. Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer. Breast Cancer Res. 9, R89 (2007)

    Article  Google Scholar 

  5. Camps, C. et al. hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin. Cancer Res. 14, 1340–1348 (2008)

    Article  CAS  Google Scholar 

  6. Wong, L., Lee, K., Russell, I. & Chen, C. Endogenous Controls for Real-Time Quantitation of miRNA Using TaqMan MicroRNA Assays <> (2007)

    Google Scholar 

  7. Iorio, M. et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65, 7065–7070 (2005)

    Article  CAS  Google Scholar 

  8. Blenkiron, C. et al. MicroRNA expression profiling of human breast cancer identifies new markers of tumour subtype. Genome Biol. 8, R214 (2007)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


PowerPoint slides

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gee, H., Camps, C., Buffa, F. et al. MicroRNA-10b and breast cancer metastasis. Nature 455, E8–E9 (2008).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing