Modifier proteins, such as ubiquitin, are passed sequentially between trios of enzymes, like batons in a relay race. Crystal structures suggest the mechanism of transfer between the first two enzymes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
This article and the paper concerned4 were published online on 14 January 2007.
References
Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).
Welchman, R. L., Gordon, C. & Mayer, R. J. Nature Rev. Mol. Cell Biol. 6, 599–609 (2005).
Bohnsack, R. N. & Haas, A. L. J. Biol. Chem. 278, 26823–26830 (2003).
Huang, D. T. et al. Nature 445, 394–398 (2007).
Walden, H. et al. Mol. Cell 12, 1427–1437 (2003).
Lois, L. M. & Lima, C. D. EMBO J. 24, 439–451 (2005).
Huang, D. T. et al. Mol. Cell 17, 341–350 (2005).
Eletr, Z. M., Huang, D. T., Duda, D. M., Schulman, B. A. & Kuhlman, B. Nature Struct. Mol. Biol. 12, 933–934 (2005).
Zheng, N. et al. Nature 416, 703–709 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Trempe, JF., Endicott, J. Pass the protein. Nature 445, 375–376 (2007). https://doi.org/10.1038/nature05564
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature05564
