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Cell death in the nervous system

Nature volume 443, pages 796802 (19 October 2006) | Download Citation

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Abstract

Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets.

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Acknowledgements

We apologize to all colleagues whose papers we were unable to cite owing to space limitations. We thank S. Rabizadeh, A. Kurakin, V. Galvan, D. Madden, L. Egger, J. Fombonne, T.-V. Nguyen, N. Rooke, K. Niazi, A. Swistowski, K. Poksay and S. Chen for critical reading of the manuscript, and M. Susag, L. Sheridan and R. Abulencia for manuscript preparation.

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Affiliations

  1. Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA.

    • Dale E. Bredesen
    • , Rammohan V. Rao
    •  & Patrick Mehlen
  2. University of California, San Francisco, 450 Parnassus, San Francisco, California 94143, USA.

    • Dale E. Bredesen
  3. Apoptosis, Cancer and Development Laboratory, Université de Lyon, Centre Léon Bérard, 28 Rue Laennee, 69008 Lyon, France.

    • Patrick Mehlen

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Competing interests

The authors declare no competing financial interests.

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Correspondence to Dale E. Bredesen.

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