Insulin-degrading enzyme is implicated in diabetes and Alzheimer's disease, but few molecular tools exist that can probe its function. A study now reveals its unusual structure and may lead to an expanded toolbox.
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Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
Molecular Neurodegeneration Open Access 14 January 2009
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Notes
*This article and the paper concerned1 were published online on 11 October 2006.
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Leissring, M., Selkoe, D. Enzyme target to latch on to. Nature 443, 761–762 (2006). https://doi.org/10.1038/nature05210
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DOI: https://doi.org/10.1038/nature05210
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