A technician discovered a 6-week-old male ferret with an eye abnormality during a morning health check. The ferret had been born in the research facility as part of a breeding colony maintained for influenza research and, prior to this observation, had had no ocular problems or developmental delays. Upon physical examination, a corneal opacity was noted in the left eye, as well as a diminished menace response. Other objective physical examination findings included a body temperature of 102.4 °F, body weight of 255 g, a heart rate of 160 beats/min, and a respiratory rate of 36 breaths/min. The animal was adequately hydrated, its mucous membranes were pink, and its capillary refill time was less than 3 s. Activity and appetite were unaffected and all other physical parameters were within normal limits.
The ferret shared a modified rabbit cage (Allentown, Allentown, NJ) with two littermates, both of which appeared healthy with no ophthalmic abnormalities. Neither parent of the 6-week-old male ferret had a history of ocular disease. The initial clinical assessment was idiopathic corneal edema, possibly from an immature cataract. No treatment was initiated at that time and the animal was monitored closely for any changes.
Two weeks later, the attending husbandry technician reported acute changes to the left eye. Upon reexamination, the left eye was markedly larger and the ferret lacked a menace response. The acute progression of clinical signs necessitated that the animal be euthanized and submitted for necropsy.
On gross examination, unilateral exophthalmos and corneal opacity in the left eye were the only abnormalities found in the ferret (Fig. 1). Both eyes were collected and fixed in 10% neutral buffered formalin, processed routinely, embedded in paraffin, and sectioned at 4 μm. Histologic findings included thin sclera, corneal edema, anterior synechia (Fig. 2), and inner retinal atrophy (Fig. 3). The anterior synechia were broad and precluded a detailed examination of the filtration angle. Retinal atrophy consisted of the loss of the ganglion cells, the inner plexiform layer, and a thin inner nuclear layer.
Figure 1 shows an obvious size difference between the right and left eye. What condition is consistent with these histological results? Is this ocular condition commonly seen in ferrets? What are other possible ocular maladies? Are any of these conditions related?
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Funk, A., Rogers, T., Dobbins, R. et al. Exophthalmos and corneal edema in a young ferret. Lab Anim 35, 19 (2006). https://doi.org/10.1038/laban1006-19
Issue Date:
DOI: https://doi.org/10.1038/laban1006-19