Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News Feature
  • Published:

Biomedical research gone to the dogs

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Tsai, K.L., Clark, L.A. & Murphy, K.E. Understanding hereditary diseases using the dog and human as companion model systems. Mamm. Genome 18, 444–451 (2007).

    Article  Google Scholar 

  2. From canine genetics to human disease: a Q&A with Cathryn Mellersh and David Sargan. Biome (18 April 2014). http://www.biomedcentral.com/biome/from-canine-genetics-to-human-disease-a-qa-with-cathryn-mellersh-and-david-sargan/

  3. Lindblad-Toh, K. et al. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438, 803–819 (2005).

    Article  CAS  Google Scholar 

  4. Karlsson, E.K. et al. Efficient mapping of mendelian traits in dogs through genome-wide association. Nat. Genet. 39, 1321–1328 (2007).

    Article  CAS  Google Scholar 

  5. Wilbe, M. et al. Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. Nat. Genet. 42, 250–254 (2010).

    Article  CAS  Google Scholar 

  6. Shearin, A.L. & Ostrander, E.A. Leading the way: canine models of genomics and disease. Dis. Model. Mech. 3, 27–34 (2010).

    Article  CAS  Google Scholar 

  7. Kijas, J.M. et al. A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Genomics 61, 101–107 (1999).

    Article  CAS  Google Scholar 

  8. Aguirre, G.D. et al. Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol. Vis. 4, 23 (1998).

    CAS  PubMed  Google Scholar 

  9. Jacobson, S.G. et al. Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch. Ophthalmol. 130, 9–24 (2012).

    Article  CAS  Google Scholar 

  10. Awano, T. et al. Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 106, 2794–2799 (2009).

    Article  CAS  Google Scholar 

  11. Karlsson, E.K. & Lindblad-Toh, K. Leader of the pack: gene mapping in dogs and other model organisms. Nat. Rev. Genet. 9, 713–725 (2008).

    Article  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Harrington, M. Biomedical research gone to the dogs. Lab Anim 43, 339–340 (2014). https://doi.org/10.1038/laban.641

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/laban.641

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing