Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Protocol Review
  • Published:

Response to Protocol Review Scenario: Designated member review

Lab Animal volume 46, pages 59–60 (2017)Cite this article

This situation asks, “Can a new 'minor' procedure, such as a small subcutaneous implant, be added to the protocol via the process of VVC if the IACUC had previously approved the methodology for the procedure, or does the procedure require IACUC review?”

The Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy; IV.B.7; ref. 1) requires that the IACUC “review and approve, require modifications in (to secure approval), or withhold approval of proposed significant changes regarding the use of animals in ongoing activities.” The National Institutes of Health issued notice NOT-OD-14-126, Guidance on Significant Changes to Animal Activities2 to help IACUCs decrease the burden for full committee review (FCR) and designated member review (DMR) for some significant protocol changes by allowing veterinary verification and consultation (VVC).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Public Health Service. Policy on Humane Care and Use of Laboratory Animals (US Department of Health and Human Services, Washington, DC, 1986; amended 2002).

  2. National Institutes of Health. Guidance on Significant Changes to Animal Activities. Notice NOT-OD-14-126. (National Institutes of Health, Washington, DC, 26 August 2014).

  3. OLAW online seminar (2016, September 8). Implementing Guidance on Significant Changes: One Institution's Experience. https://grants.nih.gov/grants/olaw/educational_resources/webinar_09082016.htm

Download references

Author information

Authors and Affiliations

  1. Division of Laboratory Animal Resources, Etue is Laboratory Animal Technician III, University of Kentucky, Lexington, KY.,

    Jeffrey J. Etue

Authors
  1. Jeffrey J. Etue
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Etue, J. Response to Protocol Review Scenario: Designated member review. Lab Anim 46, 59–60 (2017). https://doi.org/10.1038/laban.1198

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/laban.1198

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing