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Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring

Journal of Perinatology volume 35, pages 678–682 (2015)Cite this article

Subjects

Abstract

Objective:

To evaluate the effects of gestational subclinical hypothyroidism (SCH) on early neurodevelopment of offspring.

Study Design:

A prospective study included 106 infants born to mothers with gestational SCH and 106 infants born to mothers who were euthyroid during pregnancy. The neurodevelopment of 12 to 24-month-old infants was assessed and compared using the Gesell developmental test (revised version).

Results:

Infants born to mothers with gestational SCH and those born to euthyroid mothers had similar scores on the Gesell development test. No correlations were observed between maternal TSH concentration and Gesell developmental test scores of offspring. Infants born to mothers who had gestational SCH during the first trimester specifically and those born to euthyroid mothers had similar scores on the Gesell development test. No significant correlations were detected between maternal TSH concentration during the first trimester and offspring neurodevelopment.

Conclusions:

No detectable neurodevelopment deficit was observed in offspring up to 24 months old from mothers who had gestational SCH.

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Acknowledgements

This study was supported in part by the Medical Science Research Foundation of Zhejiang Province (2009A198, to XL), the Science and Technology Project of Wenzhou city (Y20130284, to LC), the Science and Technology Project of Ruian city (20093092, to XL), a Young Scientist Award from the National Science Foundation of China (81000294, to CZ), the National Science Foundation of China (81370917, to CZ) and the Research Development Fund of Wenzhou Medical University (QTJ13005, to CZ).

Author information

Author notes

  1. L-M Chen and Q-S Chen: These authors equally contributed to this work.

Authors and Affiliations

  1. Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui’an, China

    L-M Chen, E-l Ye, H Yang, L-Q Cai, M-M Peng, Z-Z Lin, L-C Yu & X-M Lu

  2. Rui’an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    L-M Chen, E-l Ye, H Yang, L-Q Cai, M-M Peng, Z-Z Lin, L-C Yu, C Zhang & X-M Lu

  3. Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China

    L-M Chen, E-l Ye, H Yang, L-Q Cai, M-M Peng, Z-Z Lin, L-C Yu, C Zhang & X-M Lu

  4. Department of Endocrinology, Wenzhou People’s Hospital, Wenzhou, China

    Q-S Chen

  5. Department of Pediatrics, Third Affiliated Hospital of Wenzhou Medical University, Rui’an, China

    G-X Jin

  6. Department of Endocrinology, Jining First People’s Hospital, Jining, China

    G-X Si

  7. ICU, Taizhou First People’s Hospital, Taizhou, China

    Q Zhang

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  1. L-M Chen
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  12. C Zhang
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Corresponding author

Correspondence to X-M Lu.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on the Journal of Perinatology website

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Cite this article

Chen, LM., Chen, QS., Jin, GX. et al. Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring. J Perinatol 35, 678–682 (2015). https://doi.org/10.1038/jp.2015.66

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