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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Galactorrhea with metoclopramide use in the neonatal unit

Journal of Perinatology volume 29, pages 391–392 (2009)Cite this article

Abstract

We report a 3½-month-old infant with trisomy 21 presenting with galactorrhea in the neonatal intensive care unit (NICU). Endocrine work-up showed a high prolactin level (64.4 ng ml−1—normal: 0.5 to 30 ng ml−1). Cessation of therapy with metoclopramide (0.2 mg kg−1 per dose q 6 h) resulted in the resolution of galactorrhea with a decrease in serum prolactin level (20.1 ng ml−1). We present this case to highlight this uncommon side effect of a commonly used medication in the NICU.

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References

  1. Forbes TR . Witch's milk and witches’ marks. Yale J Biol Med 1950; 22: 219–225.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Madlon-Kay DJ . ‘Witch's milk’. Galactorrhea in the newborn. Am J Dis Child 1986; 140: 252–253.

    Article  CAS  Google Scholar 

  3. McKiernan JF, Hull D . Breast development in the newborn. Arch Dis Child 1981; 56: 525–529.

    Article  CAS  Google Scholar 

  4. Lee C, Robertson J, Shilkofski N . Drug doses—The Harriet Lane Handbook, 17th edn. Elsevier Mosby: Philadelphia, 2005.

    Google Scholar 

  5. McKiernan JF, Hull D . Prolactin, maternal oestrogens, and breast development in the newborn. Arch Dis Child 1981; 56: 770–774.

    Article  CAS  Google Scholar 

  6. Gluckman PD, Ballard PL, Kaplan SL, Liggins GC, Grumbach MM . Prolactin in umbilical cord blood and the respiratory distress syndrome. J Pediatr 1978; 93: 1011–1014.

    Article  CAS  Google Scholar 

  7. Sultan C, Bonardet A, Bonnal B, Descomps B, De Kerleau JC, Bonnet H et al. [Plasma prolactin levels in normal children from birth to adolescence]. C R Seances Soc Biol Fil 1977; 171: 131–135.

    CAS  PubMed  Google Scholar 

  8. Parks JS, Felner EI . Hormones of the hypothalamus and pituitary. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds). Nelson Textbook of Pediatrics. Elsievier: Philadelphia, 2007.

    Google Scholar 

  9. Hibbs AM, Lorch SA . Metoclopramide for the treatment of gastroesophageal reflux disease in infants: a systematic review. Pediatrics 2006; 118: 746–752.

    Article  Google Scholar 

  10. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR . Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 2006; 117: 1979–1987.

    Article  Google Scholar 

  11. Malcolm WF, Gantz M, Martin RJ, Goldstein RF, Goldberg RN, Cotten CM . Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. Pediatrics 2008; 121: 22–27.

    Article  Google Scholar 

  12. Arroyo H, Aubert L . [Galactorrhoea following metoclopramide treatment]. Presse Med 1971; 79: 1859.

    CAS  PubMed  Google Scholar 

  13. Ehrenkranz RA, Ackerman BA . Metoclopramide effect on faltering milk production by mothers of premature infants. Pediatrics 1986; 78: 614–620.

    CAS  PubMed  Google Scholar 

  14. Hyams JS, Leichtner AM, Zamett LO, Walters JK . Effect of metoclopramide on prolonged intraesophageal pH testing in infants with gastroesophageal reflux. J Pediatr Gastroenterol Nutr 1986; 5: 716–720.

    Article  CAS  Google Scholar 

  15. Tolia V, Calhoun J, Kuhns L, Kauffman RE . Randomized, prospective double-blind trial of metoclopramide and placebo for gastroesophageal reflux in infants. J Pediatr 1989; 115: 141–145.

    Article  CAS  Google Scholar 

  16. Craig WR, Hanlon-Dearman A, Sinclair C, Taback S, Moffatt M . Metoclopramide, thickened feedings, and positioning for gastro-oesophageal reflux in children under two years. Cochrane Database Syst Rev 2004 CD003502.

  17. Madani S, Tolia V . Gynecomastia with metoclopramide use in pediatric patients. J Clin Gastroenterol 1997; 24: 79–81.

    Article  CAS  Google Scholar 

  18. Young T, Mangum B . Neofax 2008. Thomson Reuters Healthcare: Montvale, NJ, 2008; 8: 222.

    Google Scholar 

  19. van der Steen M, Du Caju MV, Van Acker KJ . Gynecomastia in a male infant given domperidone. Lancet 1982; 2: 884–885.

    Article  CAS  Google Scholar 

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  1. Women and Children's Hospital of Buffalo, Buffalo, NY, USA

    B Paturi, R M Ryan, K A Michienzi & S Lakshminrusimha

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  1. B Paturi
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  2. R M Ryan
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  3. K A Michienzi
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  4. S Lakshminrusimha
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Correspondence to S Lakshminrusimha.

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Paturi, B., Ryan, R., Michienzi, K. et al. Galactorrhea with metoclopramide use in the neonatal unit. J Perinatol 29, 391–392 (2009). https://doi.org/10.1038/jp.2008.246

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  • DOI: https://doi.org/10.1038/jp.2008.246

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