Abstract
Two new compounds, 8′-phospho derivatives of amicoumacins A and B, were isolated from the culture broth of a strain of Bacillus pumilus together with amicoumacins A and B. Their structures were elucidated on the basis of spectroscopic methods and alkaline phosphatase treatments. Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8′ hydroxyl and C-12′ amide group of amicoumacin A played a critical role for anti-MRSA activity.
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Hashimoto, M., Taguchi, T., Nishida, S. et al. Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-activity Relationship of Hydroxy Amino Acid Moiety. J Antibiot 60, 752–756 (2007). https://doi.org/10.1038/ja.2007.99
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DOI: https://doi.org/10.1038/ja.2007.99
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