Abstract
Three novel cytotoxic substances named prenylterphenyllin (1), 4″-deoxyprenylterphenyllin (2), and 4″-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4″-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1~4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC50 of 8.5, 3.0, 2.5, and 4.5 μg/ml, respectively.
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Wei, H., Inada, H., Hayashi, A. et al. Prenylterphenyllin and Its Dehydroxyl Analogs, New Cytotoxic Substances from a Marine-derived Fungus Aspergillus candidus IF10. J Antibiot 60, 586–590 (2007). https://doi.org/10.1038/ja.2007.75
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DOI: https://doi.org/10.1038/ja.2007.75
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