Abstract
YM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
References
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Sohda, Ky., Hiramoto, M., Suzumura, Ki. et al. YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis. J Antibiot 58, 32–36 (2005). https://doi.org/10.1038/ja.2005.3
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DOI: https://doi.org/10.1038/ja.2005.3
Keywords
- YM-216391
- cyclic peptide
- trisoxazole
- cytotoxic
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