Abstract
The actinomycete Streptomyces diannanensis, isolated from a soil sample collected in Yunnan province, China, was found to produce two novel isoflavone rhamnopyranosides, namely, 7,4′-dihydroxyisoflavone 3′-O-α-L-rhamnopyranoside (1) and 5,7,4′-trihydroxyisoflavone 3′-O-α-L-rhamnopyranoside (2). The structures of 1 and 2 were elucidated on the basis of extensive 1D and 2D NMR and MS spectral analyses. Compounds 1 and 2 exhibited in vitro activities against aldose reductase with an IC50 of 170 and 165 µM, respectively.
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Dong, Y., Yang, J., Ren, X. et al. New Aldose Reductase Inhibitors N99-596 A and B from Streptomyces. J Antibiot 58, 737–739 (2005). https://doi.org/10.1038/ja.2005.100
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DOI: https://doi.org/10.1038/ja.2005.100
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