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Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242

The Journal of Antibiotics volume 76, pages 699–705 (2023)Cite this article

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Abstract

Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (3), together with a known nonadride analogue (4), were characterized from the Magellan Seamount-derived fungus Talaromyces scorteus AS-242. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. X-ray crystallographic analysis of compounds 1 and 3 confirmed their structures and absolute configurations, representing the first characterized crystal structure of a nonadride-type polyketide. The isolated compounds exhibited potent antimicrobial activities against the pathogenic bacterium MRSA and V. parahaemolyticus and pathogenic fungi C. gloeosporioides, F. oxysporum, and F. proliferatum, with MIC values ranging from 1 to 64 μg ml−1.

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Funding

This work was supported by the National Natural Science Foundation of China (41976090 and 42176115), the Natural Science Foundation of Jiangsu Province (BK20201211), and the Senior User Project of RV KEXUE (KEXUE2020GZ02). B.-G.W. acknowledges the support of the Oceanographic Data Center at IOCAS (for CPU time) and the RV KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences (for sampling).

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  1. These authors contributed equally: Ying Wang, Zhen Ying.

Authors and Affiliations

  1. CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao, 266071, China

    Ying Wang, Zhen Ying, Xiao-Ming Li, Sui-Qun Yang, Hong-Lei Li, Bin-Gui Wang & Ling-Hong Meng

  2. University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing, 100049, China

    Ying Wang, Zhen Ying, Bin-Gui Wang & Ling-Hong Meng

  3. Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao, 266237, China

    Bin-Gui Wang

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Correspondence to Bin-Gui Wang or Ling-Hong Meng.

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Wang, Y., Ying, Z., Li, XM. et al. Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242. J Antibiot 76, 699–705 (2023). https://doi.org/10.1038/s41429-023-00664-5

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  • DOI: https://doi.org/10.1038/s41429-023-00664-5

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