Abstract
Diagnostic tools are presented which enable the geneticist to assess the agreement between linkage data and a fitted normal mixture model for interval mapping. The theoretical likelihood profile along a chromosome is derived for a single quantitative trait locus (QTL) segregating in a backcross population, along with upper and lower bounds. This is useful for detecting two QTLs on a chromosome. Residuals are used to indicate the need for transformation of the trait values to a different scale before analysis, and the use of an incorrect distribution is shown to reduce the maximum lod score. A strategy for the regular use of diagnostic tools for interval mapping is presented.
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Hackett, C. Model diagnostics for fitting QTL models to trait and marker data by interval mapping. Heredity 79, 319–328 (1997). https://doi.org/10.1038/hdy.1997.160
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DOI: https://doi.org/10.1038/hdy.1997.160
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