Abstract
Different polymorphic elements of the enzyme glucose-6-phosphate dehydrogenase (G6PD) are favoured under selection for long versus short life span. Replicate independently selected populations of short-lived individuals exhibit a more rapidly migrating and less actively staining allozyme, while long-lived populations have a slower migrating and more active allozyme. These correspond to the common ZwA and ZwB variants of the G6PD locus Zw. In vitro measurements show G6PD activity varies with allozymes and life span. Long-lived males have 64 per cent greater activity in G6PD, while females of long-lived strains are 108 per cent higher than those of short-lived strains. Previous studies of these strains have repeatedly demonstrated additivity of life span in F1 crosses. Activity of G6PD in reciprocal F1 populations is additive and intermediate between parents.
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Ayala, F J, Powell, J R, Tracey, M L, Mourao, C A, and Perez-Salaz, S. 1972. Enzyme variability in the Drosophila willistoni group. IV. Genetic variation in natural populations of Drosophila willistoni. Genetics, 70, 113–139.
Cavener, D R, and Clegg, M T. 1981. Evidence for bio-chemical and physiological differences between enzyme genotypes ofDrosophila melanogaster. Proc Natl Acad Sci USA, 78, 4444–4447.
Charlesworth, B. 1980. Evolution In Age-structured Populations. Cambridge University Press.
Clare, M J, and Luckinbill, L S. 1985. The effects of gene-environment interaction on the expression of longevity.Heredity, 55, 19–25.
Clark, A G, and Doan, W W. 1983. Desiccation tolerance of the adipose mutant of Drosophila melanogaster. Hereditas, 99, 165–175.
Clark, A G, and Keith, L. 1988. Variation among extracted lines of Drosophila melanogaster in triacylglycerol and carbohydrate storage. Genetics, 119, 595–607.
Cole, L C. 1954. The population consequences of life history phenomena. Quart Rev Biol, 29 103–137.
Doan, W W. 1960. Developmental physiology of the Mutant Female Sterile (2) Adipose of Drosophila melanogaster.II. Effects of altered environment and residual genome on its expression. Exp Zool, 145 23–41.
Eanes, W F. 1983. Genetic localization and sequential electro-phoresis of Glucose-6-Phosphate Dehydrogenase in Drosophila melanogaster. Biochem Genetics, 21, 703–711.
Fisher, R A. 1930. The Genetical Theory of Natural Selection. Clarendon Press, Oxford.
Flanagan, J R. 1980. Detecting earlylife components in the determination of the age of death. Mech Aging Dev, 13, 41–62.
Ganguly, R, Ganguly, N, and Manning, J E. 1985. Isolation and characterization of the glucose-6-phospate dehydrogenase gene of Drosophila melanogaster. Gene, 35, 91–101.
Geer, B W, and Laurie-Ahlberg, C C. 1984. Genetic variation in dietary sucrose modulation of enzyme activities in Drosophila melanogaster. Genet Res Camb, 43, 307–321.
Geer, B W, Krochko, D, and Williamson, J H. 1979a. Ontogeny, cell distribution and the physiological role of NADP-Malic Enzyme in Drosophila melanogaster. Biochem Genetics, 17, 867–879.
Geer, B W, Lindel, D L, and Lindell, D M. 1979b. Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster. Biochem Genetics, 17, 881–895.
Graves, J L, Luckinbill, L S, and Nichols, A. 1988. Flight duration and the measurement of wing beat frequency in long-and short-lived Drosophila melanogaster. J Insect Physiol, 34, 1021–1026.
Graves, J L, and Rose, M R. 1989. The flight/longevity correlation in Drosophila melanogaster selected for postpońed senescence. In Harrison, D. E. (ed.) Genetic Effects On Aging.
Haldane, J B S. 1941. New Paths in Genetics. Allen and Unwin, London.
Hamilton, W D. 1966. The moulding of senescence by natural selection. J Theoret Biol, 12, 12–45.
Hartl, D, and Clark, A G. 1989. Principles of Population Genetics. Sinauer Associates, pp. 78.
Hebert, P D N, and Beaton, M. 1986. Cellulose Acetate Gel Electrophoresis. University of Windsor, Ontario, Canada, 34pp.
Laurie-Ahlberg, C C, Barnes, P T, Curtsinger, J W, Emigh, T H, Karlin, B, Morris, R, Norman, R A, and Wilton, A N. 1985. Genetic variability of flight metabolism in Drosophila melanogaster. II. Relationship between power output and enzyme activity levels. Genetics, 111, 845–868.
Lints, F A, and Hoste, C. 1974. The Lansing Effect revisited. I. Life-span. Exp Geront, 9, 51–69.
Lints, F A, Stoll, J, Gruwez, G, and Lints, C V. 1979. An attempt to select for longevity in Drosophila melanogaster. Gerontology, 25, 192–204.
Lotka, A. 1925. Elements of Physical Biology. Reprinted in 1956 by Dover Publications N.Y.
Lowry, O, Rosebrough, N, Farr, A, and Randell, R. 1951. Protein measurements with the Folin phenol reagent. J Biol Chem, 193, 265–275.
Lucchesi, J C. 1973. Dosage compensation in Drosophila. Ann Rev Genetics, 7, 225–237.
Luchessi, J C. 1983. Dosage compensation in Drosophila. Isozymes: Current Topics In Biological and Medical Research 9: Gene Expression and Development, pp. 179–188.
Luckingbill, L S, Arking, R, Clare, M J, Cirocco, W, and Buck, S. 1984. Selection for delayed senescence in Drosophila melanogaster. Evolution, 38, 996–1003.
Luckinbill, L S, and Clare, M J. 1985. Selection for life span in Drosophila melanogaster. 1985. Heredity, 55, 9–18.
Luckinbill, L S, and Clare, M J. 1986. A density threshold for the expression of longevity in Drosophila melanogaster. Heredity, 56, 329–335.
Luckinbill, L S, Clare, M J, Krell, W K, Cirocco, W C, and Richards, P A. 1987. Estimating the numbers of genetic elements that defer senescence in Drosophila. Evolutionary Ecology, 1, 37–46.
Luckinbill, L S, Graves, J L, Reed, A H, and Koet-Sawang, S. 1988a. Localizing genes that defer senescence in Drosophila melanogaster. Heredity, 60, 367–374.
Luckingbill, L S, Graves, J L, Tomkiu, A, and Sowirka, O. 1988b. A qualitative analysis of some life history correlates of longevity in Drosophila melanogaster. Evolutionary Ecology, 2, 85–94.
Luckinbill, L S, Grudzien, T A, Rhine, S, and Weisman, G. 1989. The genetic basis of adaptation to selection for longevity in Drosophila melanogaster. Evolutionary Ecology, 3, 31–39.
Miyashita, N, and Laurie-Ahlberg, C. 1986. Developmental variation in effects of the second and third chromosomes on the activities of Glucose-6-phosphate and 6-Phosphogluconmate dehydrogenases in Drosophila melanogaster. Biochem Genetics, 24, 447–467.
Miyashita, N, Laurie-Ahlberg, C, Wilton, A N, and Emigh, T H. 1986. Quantitative analysis of X chromosome effects on the activities of the Glucose-6-phosphate and 6-phosphogluconate dehydrogenases of Drosophila melanogaster. Genetics, 113, 321–335.
Medawar, P B. 1952. An Unsolved Probelm in Biology. H. K. Lewis, London.
Ramshaw, A J, Coyne, J A, and Lewontin, R C. 1979. The sensitivity of gel electrophoresis as a detector of genetic variation. Genetics, 93, 1019–1037.
Rhine, S. (unpublished). Quantitative and Mendelian Factors Associated with the Increased Life Span of Selectively Bred Drosophila melanogaster. M.S. Thesis, Wayne State University.
Richmond, R C. 1972. Enzyme variability in the Drosophila willistoni group III. Amounts of variability in the super-species, D. paulistorum. Genetics, 70, 87–112.
Rose, M R. 1984. Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution, 38, 1004–1010.
Rose, M R, and Charlesworth, B. 1981. Genetics of life history in Drosophila melanogaster II. Exploratory selection experiments. Genetics, 97, 187–196.
Service, P M. 1987. Physiological mechanisms of increased stress resistance in Drosophila melanogaster selected for postponed senescence. Physiol Zool, 60, 321–326.
Service, P M, Hutchinson, E W, Mackinley, M D, and Rose, M R. 1985. Resistance to environment stress in Drosophila melanogaster selected for postponed senescence. Physiol Zool, 58, 380–389.
Service, P M, Hutchinson, E W, and Rose, M R. 1988. Multiple genetic mechanisms for the evolution of senescence in Drosophila melanogaster. Evolution, 42 708–716.
Wattiaux, J M. 1968. Cumulative parental age effects in Drosophila subobscura. Evolution, 22, 406–421.
Wiggles Worth, V B. 1949. The utilization of reserve substances in Drosophila during flight. J Exp Biol, 26, 150–163.
Williams, G C. 1957. Pleiotropy, natural selection and the evolution of senescence. Evolution, 11, 398–411.
Williamson, J W, and Bentley, M M. 1983. Comparative properties of three forms of Glucose-6-phosphate de-hydrogenase in Drosophila melanogaster. Biochem Gen, 21, 1153–1166.
Wood, T. 1985. The Pentose Phosphate Pathway. Academic Press.
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Luckinbill, L., Riha, V., Rhine, S. et al. The role of glucose-6-phosphate dehydrogenase in the evolution of longevity in Drosophila melanogaster. Heredity 65, 29–38 (1990). https://doi.org/10.1038/hdy.1990.66
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DOI: https://doi.org/10.1038/hdy.1990.66