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Lipids and cardiovascular/metabolic health

Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

European Journal of Clinical Nutrition volume 69, pages 717–721 (2015)Cite this article

Subjects

Abstract

Background/Objectives:

Neuropeptide Y (NpY) is an important factor in neuropeptide signalling, and significantly change in the blood and cerebrospinal fluid (CSF) during chronic kidney disease (CKD) progression. However, the role of NpY remains unclear. We aimed to investigate the associations between NpY levels, nutritional status and cardiovascular disease (CVD) in patients with CKD.

Subjects/Methods:

In this cohort study, we performed Pearson's correlation analysis and multiple linear regressions to assess the relationship between CSF and serum NpY levels, as well as nutritional indices. Receiver operating characteristic curves were used to evaluate the sensitivity and specificity of CSF NpY levels. As NpY affects the cardiovascular system, Kaplan–Meier analysis was used to investigate the relationship between serum NpY levels and CVD.

Results:

CSF NpY levels and nutritional indices were related during CKD progression (energy intake: β=0.236, P<0.001; mid-arm muscle circumference: β=0.953, P=0.014; prealbumin: β=0.067, P<0.001), and had high specificity (79.9%). High serum NpY levels may be a risk factor associated with CVD (relative risk=1.8015, 95% confidence interval: 1.0509–3.0881).

Conclusions:

Our results suggested a relationship between CSF NpY levels and nutritional indices in CKD patients. High serum NpY concentrations may be a risk factor associated with CVD.

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Acknowledgements

This research is supported by the National Science Foundation of China (Nos. 81173457 and 81001674).

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Authors and Affiliations

  1. Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou, China

    Y-F Huang, D-X Chen & L-B Wei

  2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China

    L Lu, Y-C Zou, Y-F Huang, D-X Chen & L-B Wei

  3. Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, China

    M Wang, Y-F Huang, D-X Chen & L-B Wei

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  1. L Lu
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Correspondence to L-B Wei.

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We declare that we have no financial or personal relationships with other people or organisations that can inappropriately influence our work; there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, this manuscript.

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Lu, L., Zou, YC., Wang, M. et al. Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease. Eur J Clin Nutr 69, 717–721 (2015). https://doi.org/10.1038/ejcn.2015.67

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