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  • RESEARCH HIGHLIGHT

Why the immune response to a vaccine varies from person to person

A dormant immune system before receiving the BCG vaccine is tied to a greater innate immune response afterwards.
Coloured scanning electron micrograph (SEM) of a neutrophil white blood cell.

Cells called neutrophils (artificially coloured) are part of the innate immune response triggered by BCG vaccination. Credit: Science Photo Library

A DNA signature might explain why a century-old vaccine rouses the immune system more strongly in some people than in others1.

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Nature 625, 427 (2024)

doi: https://doi.org/10.1038/d41586-024-00005-y

References

  1. Moorlag, S. J. C. F. M. et al. Immunity https://doi.org/10.1016/j.immuni.2023.12.005 (2024).

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