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Soft-landing methods aim to simplify structural biology

Linking mass spectrometry with cryo-electron microscopy could transform understanding of complex protein structures — if scientists can show that samples remain intact when they hit their target.
  1. Michael Eisenstein

    1. Michael Eisenstein is a freelance writer based in Philadelphia, Pennsylvania.

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In his lecture after winning a share of the 2002 Nobel Prize in Chemistry, John Fenn described his work as creating “wings for molecular elephants”.

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Nature 622, 658-660 (2023)

doi: https://doi.org/10.1038/d41586-023-03236-7

Updates & Corrections

  • Correction 19 October 2023: An earlier version of this Technology feature erroneously referred to Ljiljana Paša-Tolić as a mass-spectroscopy specialist.

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