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  • RESEARCH BRIEFINGS

Mechanism of messenger-RNA decoding in humans illuminated

Intracellular machines called ribosomes use messenger-RNA sequences to synthesize proteins. Investigations using single-molecule imaging and cryo-electron microscopy techniques reveal structural and kinetic differences in how human ribosomes function compared with those of bacteria. These differences explain why ribosomes in cell-nucleus-bearing species are slower and more accurate than their bacterial counterparts.

This is a summary of: Holm, M. et al. mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature https://doi.org/10.1038/s41586-023-05908-w (2023).

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doi: https://doi.org/10.1038/d41586-023-00727-5

Figure 1 is published under a CC BY 4.0 licence.

References

  1. Voorhees, R. M. & Ramakrishnan, V. Annu. Rev. Biochem. 82, 203–236 (2013).

    Article  PubMed  Google Scholar 

  2. Kramer, E. B., Vallabhaneni, H., Mayer, L. M. & Farabaugh, P. J. RNA 16, 1797–1808 (2010).

    Article  PubMed  Google Scholar 

  3. Budkevich, T. V. et al. Cell 158, 121–131 (2014).

    Article  PubMed  Google Scholar 

  4. Xu, Y. & Ruggero, D. Annu. Rev. Cancer Biol. 4, 437–457 (2020).

    Article  Google Scholar 

  5. Wu, C. C.-C., Peterson, A., Zinshteyn, B., Regot, S. & Green, R. Cell 182, 404–416 (2020).

    Article  PubMed  Google Scholar 

Download references

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