Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Huge trial yields disappointing results on colonoscopy benefits

Three-dimensional fluorescence micrograph of human colon cancer cells in green and purple colours

Human colon-cancer cells. A randomized trial failed to show that the screening technique called colonoscopy strongly reduces deaths from colorectal cancer. Credit: Dr Torsten Wittmann/Science Photo Library

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Nature 610, 423 (2022)



  1. Bretthauer, M. et al. N. Engl. J. Med. (2022).

    Article  Google Scholar 

Download references


Nature Careers


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing


Quick links