Young cerebrospinal fluid improves memory in old mice

Zawadzki, Miriam; Lehtinen, Maria K.

doi:10.1038/d41586-022-00860-7

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11 May 2022

Young cerebrospinal fluid improves memory in old mice

Infusion of cerebrospinal fluid from young mice into old mice restores memory recall in the aged animals by triggering production of the fatty myelin sheath that insulates neurons in the brain.

Miriam Zawadzki ⁰ &
Maria K. Lehtinen ¹

Miriam Zawadzki
1. Miriam Zawadzki is in the Department of Pathology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA.
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Maria K. Lehtinen
1. Maria K. Lehtinen is in the Department of Pathology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA.
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Age-related cognitive decline affects up to one-quarter of adults over the age of sixty¹. A healthy diet and regular exercise can help to prevent this decline, but as yet there are no treatments to reverse it². Progress in understanding how the brain changes during development and ageing has sparked tantalizing ideas for harnessing youthful factors to slow age-associated cognitive changes — or even to rejuvenate the ageing brain. Writing in Nature, Iram et al.³ bolster this line of thinking by tapping into the cerebrospinal fluid (CSF), which bathes the brain tissue and contains several protein growth factors necessary for normal brain development.

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Nature 605, 428-429 (2022)

doi: https://doi.org/10.1038/d41586-022-00860-7

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