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  • RESEARCH HIGHLIGHT

Canine CRISPR trial raises hopes for humans with deadly disease

Dogs with a disorder similar to Duchenne muscular dystrophy improve after gene-editing treatment.
Restoration of dystrophin in diaphragm treated with CRISPR

Muscle from a healthy dog (left panel) includes the protein dystrophin (green); this is missing (centre) in tissue from a dog with a muscle-wasting disease but can be restored (right) by a gene-editing regimen. Credit: UT Southwestern

A powerful gene-editing technique can stimulate dogs’ production of an important muscle protein, a finding that takes researchers a step closer to trying the technology in humans who have a fatal deficit in the same molecule.

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Nature 561, 9 (2018)

doi: https://doi.org/10.1038/d41586-018-06142-5

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