The peptide-loading complex is key to the initiation of an immune response that raises killer T cells in vertebrates. Its structure has now been determined, and might provide information that improves immune protection.
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References
Blees, A. et al. Nature 551, 525–528 (2017).
Rock, K. L., Reits, E. & Neefjes, J. Trends Immunol. 37, 724–737 (2016).
Ljunggren, H.-G. et al. Nature 346, 476–480 (1990).
Ellgaard, L., McCaul, N., Chatsisvili, A. & Braakman, I. Traffic 17, 615–638 (2016).
Hill, A. et al. Nature 375, 411–415 (1995).
Dong, G., Wearsch, P. A., Peaper, D. R. & Cresswell, P. & Reinisch, K. M. Immunity 30, 21–32 (2009).
Frickel, E.-M. et al. Proc. Natl Acad. Sci. USA 99, 1954–1959 (2002).
Oldham, M. L et al. Nature 529, 537–540 (2016).
Reits, E. A. J., Vos, J. C., Grommé, M & Neefjes, J. Nature 404, 774–778 (2000).
Thomas, C. & Tampé, R. Science https://doi.org/10.1126/science.aao6001 (2017).
Jiang, J. et al. Science https://doi.org/10.1126/science.aao5154 (2017).
Schuren, A. B. C., Costa, A. I. & Wiertz, E. J. H. J. Curr. Opin. Immunol. 40, 43–50 (2016).
Yarchoan, M., Johnson. B. A. III, Lutz, E. R., Laheru, D. A. & Jaffee, E. M. Nature Rev. Cancer 17, 209–222 (2017).
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Ploegh, H. Machinery that guides immunity. Nature 551, 442–443 (2017). https://doi.org/10.1038/d41586-017-07268-8
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DOI: https://doi.org/10.1038/d41586-017-07268-8
- Structural biology
- Immunology