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Histocompatibility and Donor Selection Issues

Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study

Bone Marrow Transplantation volume 50, pages 232–236 (2015)Cite this article

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Abstract

We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII–IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09–2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00–1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.

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Acknowledgements

We thank Dr Caroline Le Gall and Dr Pierre-Antoine Gourraud (Methodomics, Toulouse, France) for their support concerning statistical analysis, Dr Céline Clément (Agence de la Biomédecine, La Plaine Saint-Denis, France) for her help concerning extractions of HLA typing from French registry and Dr Florent Malard (CHU Hotel Dieu, Nantes, France) for his comments. This work was supported by grants from IRGHET (International Research Group on HEmatopoeitic cell Transplantation).

Author information

Authors and Affiliations

  1. HLA Laboratory, EFS Nantes, Nantes, France,

    K Gagne & A Cesbron

  2. EA4271 EFS Nantes, Nantes, France,

    K Gagne

  3. Labex Transplantex, Université Strasbourg, Strasbourg, France,

    K Gagne, P Loiseau & A Cesbron

  4. HLA Laboratory, Inserm UMR940, AP-HP Paris Saint Louis,

    P Loiseau

  5. HLA Laboratory, EFS Lyon, Lyon, France,

    V Dubois

  6. HLA Laboratory, CHU Lille, Lille, France,

    F Dufossé

  7. HLA Laboratory, CHU Nancy, Nancy, France,

    P Perrier

  8. HLA Laboratory, EFS Besançon, Besancon, France,

    A Dormoy

  9. HLA Laboratory, EFS Poitiers, Poitiers, France,

    I Jollet

  10. HLA Laboratory, EFS Rennes, Rennes, France,

    V Renac

  11. HLA Laboratory, EFS Grenoble, Grenoble, France,

    D Masson

  12. HLA Laboratory, UMR 7268 Université Aix-Marseille, EFS Marseille, Marseille, France,

    C Picard

  13. HLA Laboratory, EFS Bordeaux, Bordeaux, France,

    X Lafarge

  14. HLA Laboratory, EFS Strasbourg, Strasbourg, France,

    D Hanau

  15. HLA Laboratory, EFS Clermont-Ferrand, Clermont-Ferrand, France,

    F Quainon

  16. HLA Laboratory, AP-HP Paris Créteil, Paris, France,

    F Delbos

  17. HLA Laboratory, EFS Angers, Angers, France,

    B Coeffic

  18. HLA Laboratory, EFS Saint-Etienne, Saint-Etienne, France,

    Léna Absi

  19. HLA Laboratory, CHU Montpellier, Montpellier, France,

    J-F Eliaou

  20. Société Francophone d’Histocompatibilité et d’Immunogénétique (SFHI), Paris, France,

    J-F Eliaou

  21. HLA Laboratory, CHU Brest, Brest, France,

    V Moalic

  22. HLA Laboratory, CHU Toulouse, Toulouse, France,

    M Fort

  23. HLA Laboratory, CHU Nice, Nice, France,

    M de Matteis

  24. HLA Laboratory, AP-HP Paris Pitié Salpetrière, Paris, France,

    I Theodorou

  25. HLA Laboratory, EFS Rouen, Rouen, France,

    F Hau

  26. HLA Laboratory, EFS Caen, Caen, France,

    A Batho

  27. HLA Laboratory, AP-HP Paris Robert Debré, Paris, France,

    B Pedron

  28. HLA Laboratory, AP-HP Paris Necker, Paris, France,

    S Caillat-Zucman

  29. Registre France Greffe de Moelle (RFGM), Saint Denis La Plaine, France,

    E Marry

  30. Hematology Department, Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), University Hospital, Lille, France,

    N Raus & I Yakoub-Agha

Authors
  1. K Gagne
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  2. P Loiseau
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  15. B Coeffic
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  16. Léna Absi
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  18. V Moalic
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  19. M Fort
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  20. M de Matteis
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  21. I Theodorou
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  22. F Hau
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  23. A Batho
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  24. B Pedron
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  25. S Caillat-Zucman
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  26. E Marry
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  28. I Yakoub-Agha
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  29. A Cesbron
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on behalf of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and the Société Francophone d'Histocompatibilité et d'Immunogénétique (SFHI)

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Correspondence to A Cesbron.

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Gagne, K., Loiseau, P., Dubois, V. et al. Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study. Bone Marrow Transplant 50, 232–236 (2015). https://doi.org/10.1038/bmt.2014.253

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