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Allografting

Allogeneic hematopoietic cell transplantation for neuroblastoma: the CIBMTR experience

Bone Marrow Transplantation volume 48, pages 1056–1064 (2013)Cite this article

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Abstract

Although the role of autologous hematopoietic cell transplantation (auto-HCT) is well established in neuroblastoma (NBL), the role of allogeneic HCT (allo-HCT) is controversial. The Center for International Blood and Marrow Transplant Research conducted a retrospective review of 143 allo-HCT for NBL reported in 1990–2007. Patients were categorized into two different groups: those who had not (Group 1) and had (Group 2) undergone a prior auto-HCT (n=46 and 97, respectively). One-year and five-year OS were 59% and 29% for Group 1 and 50% and 7% for Group 2, respectively. Among donor types, disease-free survival (DFS) and OS were significantly lower for unrelated transplants at 1 and 3 years but not at 5 years post HCT. Patients in CR or very good partial response (VGPR) at transplant had lower relapse rates and better DFS and OS, compared with those not in CR or VGPR. Our analysis indicates that allo-HCT can cure some neuroblastoma patients, with lower relapse rates and improved survival in patients without a history of prior auto-HCT as compared with those patients who had previously undergone auto-HCT. Although the data do not address why either strategy was chosen for patients, allo-HCT after a prior auto-HCT appears to offer minimal benefit. Disease recurrence remains the most common cause of treatment failure.

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Acknowledgements

The CIBMTR is supported by Public Health Service Grant/Cooperative Agreement U24-CA76518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); a Grant/Cooperative Agreement 5U01HL069294 from NHLBI and NCI; a contract HHSH234200637015C with Health Resources and Services Administration (HRSA/DHHS); two Grants N00014-06-1-0704 and N00014-08-1-0058 from the Office of Naval Research; and grants from Allos, Inc.; Amgen, Inc.; Angioblast; Anonymous donation to the Medical College of Wisconsin; Ariad; Be the Match Foundation; Blue Cross and Blue Shield Association; Buchanan Family Foundation; CaridianBCT; Celgene Corporation; CellGenix, GmbH; Children’s Leukemia Research Association; Fresenius-Biotech North America, Inc.; Gamida Cell Teva Joint Venture Ltd.; Genentech, Inc.; Genzyme Corporation; GlaxoSmithKline; HistoGenetics, Inc.; Kiadis Pharma; The Leukemia and Lymphoma Society; The Medical College of Wisconsin; Merck & Co, Inc.; Millennium: The Takeda Oncology Co.; Milliman USA, Inc.; Miltenyi Biotec, Inc.; National Marrow Donor Program; Optum Healthcare Solutions, Inc.; Osiris Therapeutics, Inc.; Otsuka America Pharmaceutical, Inc.; RemedyMD; Sanofi; Seattle Genetics; Sigma-Tau Pharmaceuticals; Soligenix, Inc.; StemCyte, A Global Cord Blood Therapeutics Co.; Stemsoft Software, Inc.; Swedish Orphan Biovitrum; Tarix Pharmaceuticals; Teva Neuroscience, Inc.; THERAKOS, Inc.; and Wellpoint, Inc. The views expressed in this article do not reflect the official policy or position of the National Institute of Health, the Department of the Navy, the Department of Defense, or any other agency of the US Government.

Author information

Authors and Affiliations

  1. Department of Blood and Marrow Transplant Program, All Children’s Hospital, St Petersburg, FL, USA

    G A Hale

  2. Division of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, MN, USA

    M Arora

  3. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA

    K W Ahn

  4. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA

    W He

  5. Midwest Center for Cancer and Blood Disorders, Medical College of Wisconsin and Children’s Hospital of Wisconsin, Milwaukee, WI, USA

    B Camitta

  6. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA

    M R Bishop

  7. Department of Pediatric Hematology/Oncology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel

    M Bitan

  8. Department of Pediatric Hematology/Oncology Stem Cell Transplantation, New York Medical College, Valhalla, NY, USA

    M S Cairo

  9. Department of Pediatrics, Texas Transplant Institute, San Antonio, TX, USA

    K Chan

  10. Hematology Branch, National Heart Lung and Blood Institute – NIH, Bethesda, MD, USA

    R W Childs

  11. Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Foundation, Cleveland, OH, USA

    E Copelan

  12. Department of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    S M Davies, S Jodele & K C Myers

  13. Servicio de Oncohematologia, Hospital Infantil Universitario Nino Jesus, Madrid, Spain

    M A D Perez & M G Vicent

  14. Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada

    J J Doyle

  15. Division of Experimental Medicine, Department of Medicine, Section of Hematology, Imperial College, London, UK

    R P Gale

  16. Department of Pediatrics, University of California San Francisco Medical Center, San Francisco, CA, USA

    B N Horn

  17. Department of Bone Marrow and Stem Cell Transplantation, King Hussein Cancer Center, Amman, Jordan

    A A Hussein

  18. Center for Cancer and Bloor Disorders, Children’s National Medical Center, Washington, DC, USA

    N R Kamani

  19. Department of Pediatrics, University of North Carolina Hospitals, Chapel Hill, NC, USA

    K A Kasow

  20. Department of Pediatrics, Ann and Robert H Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    M Kletzel

  21. Department of Pediatrics Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH, USA

    H M Lazarus

  22. Department of Pediatrics Hematology/Oncology, Alberta Children’s Hospital, Calgary, Alberta, Canada

    V A Lewis

  23. Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Centre for Allogeneic Stem Cell Transplantation, Stockholm, Sweden

    R Olsson

  24. Department of Hematology, Primary Children’s Medical Center, Salt Lake City, UT, USA

    M Pulsipher

  25. Department of Pediatric Hematology/Oncology, Children’s Healthcare of Atlanta at Egleston Atlanta, GA, USA

    M Qayed

  26. Department of Clinical Research Division. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    J E Sanders

  27. Department of BMT Services, The Children’s Hospital at Westmead, Sydney, New South Wales, Australia

    P J Shaw

  28. Department of Blood and Marrow Transplant Program Division of Hematology/Oncology, Nationwide Children’s Hospital, Columbus, OH, USA

    S Soni

  29. Department of Hematology/Oncology, Loyola University Medical Center, Maywood, IL, USA

    P J Stiff

  30. Department of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA, USA

    E A Stadtmauer

  31. Department of Breast Medical Oncology, M.D. Anderson Cancer Center, Houston, TX, USA

    N T Ueno

  32. Manitoba Blood and Marrow Transplant Program, CancerCare Manitoba/University of Manitoba, Winnipeg, Manitoba, Canada

    D A Wall

  33. Department of Pediatrics/Division of Oncology, Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    S A Grupp

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  1. G A Hale
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Correspondence to M Arora.

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Hale, G., Arora, M., Ahn, K. et al. Allogeneic hematopoietic cell transplantation for neuroblastoma: the CIBMTR experience. Bone Marrow Transplant 48, 1056–1064 (2013). https://doi.org/10.1038/bmt.2012.284

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