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Neurodegenerative disorders

Neural synchronization in Alzheimer's disease

Electrical oscillations generated by neural circuits are disrupted in Alzheimer's disease. Restoring these oscillations in mouse models activates immune cells to clear disease-associated amyloid-β protein from the brain. See Article p.230

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Figure 1: Gamma oscillations stimulate the clearance of amyloid-β protein deposits.


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Correspondence to Bruce A. Yankner.

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Aron, L., Yankner, B. Neural synchronization in Alzheimer's disease. Nature 540, 207–208 (2016).

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