Research Highlights | Published:

Cell biology

Immune cell aids vascular repair

Nature volume 533, pages 148149 (12 May 2016) | Download Citation

White blood cells that gobble up cellular debris also help to heal damaged blood vessels in the brain.

Deqin Yang at Chongqing Medical University and Lingfei Luo at Southwest University, Beibei in Chongqing, China, and their co-workers used lasers to rupture blood vessels in the brains of zebrafish. They monitored the events that followed with time-lapse microscopy, and saw the immune cells, called macrophages, migrate to the damaged area. A macrophage extended projections that adhered to the broken ends of the blood vessels and pulled them together by mechanical traction. In zebrafish engineered to lack macrophages, cerebral blood vessels healed more slowly than in normal animals.

The findings expand on the known roles of macrophages in the brain, the authors say.

Immunity http://doi.org/bgrv (2016)

About this article

Publication history

Published

DOI

https://doi.org/10.1038/533148e

Authors

    Comments

    By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

    Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing