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Blindness

Assassins of eyesight

A molecular cascade involving the transcription factor SIX6 and its target gene p16INK4a causes the death of neurons that link the eye to the brain. This discovery deepens our understanding of a common form of blindness, glaucoma.

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Figure 1: Molecular pathways that underlie glaucoma.

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Correspondence to Andrew D. Huberman or Rana N. El-Danaf.

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Huberman, A., El-Danaf, R. Assassins of eyesight. Nature 527, 456–457 (2015). https://doi.org/10.1038/527456a

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