A human antibody against dengue virus serotype 2 has been shown to protect mice against disease. Structures of the antibody bound to the virus illuminate how it binds different viral forms to prevent virus entry into cells.
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Bhatt, S. et al. Nature 496, 504–507 (2013).
Murphy, B. R. & Whitehead S. S. Annu. Rev. Immunol. 29, 587–619 (2011).
Fibriansah, G. et al. Science 349, 88–91 (2015).
Kuhn, R. J. et al. Cell 108, 717–725 (2002).
Fibriansah, G. et al. J. Virol. 87, 7585–7592 (2013).
Zhang, X. et al. Proc. Natl Acad. Sci. USA 110, 6795–6799 (2013).
de Alwis, R. et al. Proc. Natl Acad Sci. USA 109, 7439–7444 (2012).
Burke, D. S., Nisalak, A., Johnson, D. E. & Scott, R. M. Am. J. Trop. Med. Hyg. 38, 172–180 (1988).
Halstead, S. B. Adv. Virus Res. 60, 421–467 (2003).
Dejnirattisai, W. et al. Nature Immunol. 16, 170–177 (2015).
Rouvinski, A. et al. Nature 520, 109–113 (2015).
Dowd, K. A. & Pierson, T. C. Virology 411, 306–315 (2011).
Kuhn, R. J., Dowd, K. A., Post, C. B. & Pierson, T. C. Virology 479–480, 508–517 (2015).
Teoh, E. P. et al. Sci. Transl. Med. 4, 139ra83 (2012).
Kaufmann, B. et al. Proc. Natl Acad. Sci. USA 107, 18950–18955 (2010).
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Goo, L., Pierson, T. Bumps in the road to therapeutic antibodies. Nature 524, 295–296 (2015). https://doi.org/10.1038/524295a