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Organic chemistry

One catalyst, two reactions


A catalyst has been tuned to make different compounds from the same molecules in carbon–nitrogen bond-forming reactions, depending on the conditions used. The products are potential building blocks for biologically active molecules.

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Figure 1: Selective hydroamination reactions of alkynes.


  1. Shi, S.-L. & Buchwald, S. L. Nature Chem. 7, 38–44 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Anastas, P. & Eghbali, N. Chem. Soc. Rev. 39, 301–312 (2010).

    Article  CAS  Google Scholar 

  3. Müller, T. E., Hultzsch, K. C., Yus, M., Foubelo, F. & Tada, M. Chem. Rev. 108, 3795–3892 (2008).

    Article  Google Scholar 

  4. Hannedouche, J. & Schulz, E. Chem. Eur. J. 19, 4972–4985 (2013).

    Article  CAS  Google Scholar 

  5. Zhu, S., Niljianskul, N. & Buchwald, S. L. J. Am. Chem. Soc. 135, 15746–15749 (2013).

    Article  CAS  Google Scholar 

  6. Miki, Y., Hirano, K., Satoh, T. & Miura, M. Angew. Chem. Int. Edn 52, 10830–10834 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Emmanuelle Schulz.

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Schulz, E. One catalyst, two reactions. Nature 517, 280–281 (2015).

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