Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Physical chemistry

Hydrophobic interactions in context

The finding that immobilized ions can alter the strength of hydrophobic interactions between molecules suggests a strategy for tuning hydrophobicity to optimize molecular recognition and self-assembly processes. See Letter p.347

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Context-dependent hydrophobic interactions.


  1. Chandler, D. Nature 437, 640–647 (2005).

    ADS  CAS  Article  Google Scholar 

  2. Ma, C. D., Wang, C., Acevedo-Vélez, C., Gellman, S. H. & Abbott, N. L. Nature 517, 347–350 (2015).

    ADS  CAS  Article  Google Scholar 

  3. Patel, A. J. & Garde S. J. Phys. Chem. B 118, 1564–1573 (2014).

    CAS  Article  Google Scholar 

  4. Giovambattista, N., Debendetti, P. G. & Rossky, P. J. J. Phys. Chem. C 111, 1323–1332 (2007).

    CAS  Article  Google Scholar 

  5. Jungwirth, P. & Cremer, P. S. Nature Chem. 6, 261–263 (2014).

    ADS  CAS  Article  Google Scholar 

  6. Patel, A. J. et al. J. Phys. Chem. B 116, 2498–2503 (2012).

    CAS  Article  Google Scholar 

  7. Werner, J. et al. J. Phys. Chem. B 118, 7119–7127 (2014).

    CAS  Article  Google Scholar 

  8. Mason, P. E. et al. J. Am. Chem. Soc. 126, 11462 (2004).

    CAS  Article  Google Scholar 

  9. Shih, O. et al. J. Chem. Phys. 139, 035104 (2013).

    ADS  Article  Google Scholar 

  10. Perchiacca, J. M., Ladiwala, A. R. A., Bhattacharya, M. & Tessier, P. M. Protein Eng. Design Select. 25, 591–602 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Shekhar Garde.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Garde, S. Hydrophobic interactions in context. Nature 517, 277–279 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing