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Stem cells

A designer's guide to pluripotency

Nature volume 516, pages 172–173 (2014)Cite this article

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Pluripotent stem cells, which give rise to almost all cell types, can be engineered from mature cells. A thorough analysis of the process has led to the characterization of a new type of pluripotent cell. See Articles p.192 & p.198

These five manuscripts are part of an international collaboration called Project Grandiose, in which the researchers set out to reanalyse the process of iPSC reprogramming from an unbiased perspective. They reasoned that, by extensively documenting the molecular and cellular transitions occurring at each stage of the process, they could provide both the first thorough roadmap for iPSC reprogramming, and an explanation for the emergence during reprogramming of undefined pluripotent cell types, which have been mostly overlooked by previous studies.

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Figure 1: Different flavours of pluripotency.

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Authors and Affiliations

  1. Jun Wu and Juan Carlos Izpisua Belmonte are in the Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.,

    Jun Wu & Juan Carlos Izpisua Belmonte

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  1. Jun Wu
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  2. Juan Carlos Izpisua Belmonte
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Correspondence to Juan Carlos Izpisua Belmonte.

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Wu, J., Belmonte, J. A designer's guide to pluripotency. Nature 516, 172–173 (2014). https://doi.org/10.1038/516172a

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