Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Organic chemistry

Reactivity tamed one bond at a time


A catalyst that couples together three reactants to form just one compound out of several possibilities, as a single mirror-image isomer, should simplify the synthesis of biologically relevant molecules. See Article p.367

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: One catalyst rules all.


  1. 1

    Meng, F., McGrath, K. P. & Hoveyda, A. H. Nature 513, 367–374 (2014).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Keasling, J. D., Mendoza, A. & Baran, P. S. Nature 492, 188–189 (2012).

    ADS  CAS  Article  Google Scholar 

  3. 3

    de Graaff, C., Ruijter, E. & Orru, R. V. A. Chem. Soc. Rev. 41, 3969–4009 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Joule, J. A. & Mills, K. Heterocyclic Chemistry 5th edn (Blackwell, 2010).

    Google Scholar 

  5. 5

    Noyori, R. Asymmetric Catalysis in Organic Synthesis (Wiley, 1994).

    Google Scholar 

  6. 6

    Meng, F., Jang, H., Jung, B. & Hoveyda, A. H. Angew. Chem. Int. Edn 52, 5046–5051 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Czuba, I. R., Zammit, S. & Rizzacasa, M. A. Org. Biomol. Chem. 1, 2044–2056 (2003).

    CAS  Article  Google Scholar 

  8. 8

    Kuttruff, C. A., Eastgate, M. D. & Baran, P. S. Nat. Prod. Rep. 31, 419–432 (2014).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Phil S. Baran.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Villaume, M., Baran, P. Reactivity tamed one bond at a time. Nature 513, 324–325 (2014).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing