A comparison of identical human twins, only one of whom has Down's syndrome, reveals a genome-wide flattening of gene-expression levels in the affected individual. See Article p.345
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
LeJeune, J., Gautier, M. & Turpin, R. C.R. Hebd. Séanc. Acad. Sci. 248, 602–603 (1959).
Letourneau, A. et al. Nature 508, 345–350 (2014).
Dahoun, S. et al. Am. J. Med. Genet. A 146A, 2086–2093 (2008).
Guelen, L. et al. Nature 453, 948–951 (2008).
Hiratani, I. et al. PLoS Biol. 6, e245 (2008).
Davisson, M. T. et al. Prog. Clin. Biol. Res. 384, 117–133 (1993).
Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).
Li, B., Carey, M. & Workman, J. L. Cell 128, 707–719 (2007).
Catez, F., Brown, D. T., Misteli, T. & Bustin, M. EMBO Rep. 3, 760–766 (2002).
Liu, X., Wu, B., Szary J., Kofoed, E. M. & Schaufele, F. J. Biol. Chem. 282, 20868–20876 (2007).
Hassold, T. & Hunt, P. Nature Rev. Genet. 2, 280–291 (2001).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Pope, B., Gilbert, D. Up and down in Down's syndrome. Nature 508, 323–324 (2014). https://doi.org/10.1038/508323a
Published:
Issue Date:
DOI: https://doi.org/10.1038/508323a
This article is cited by
-
Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart
Cardiovascular Toxicology (2016)