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Cancer

Clonal cooperation

Widespread genetic heterogeneity in cells of human tumours poses a question: what prevents the fittest clone from taking over? A demonstration of interdependence between distinct clones might shed light on this puzzle. See Letter p.113

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Figure 1: Luminal and basal clones cooperate to form mammary tumours.

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Correspondence to Kornelia Polyak.

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Polyak, K., Marusyk, A. Clonal cooperation. Nature 508, 52–53 (2014). https://doi.org/10.1038/508052a

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