Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.
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H.R.C owns equity in Agios, a biotechnology company developing IDH inhibitors.
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Krall, A., Christofk, H. A metabolic metamorphosis. Nature 496, 38–40 (2013). https://doi.org/10.1038/496038a
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DOI: https://doi.org/10.1038/496038a
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