A large-scale study sheds light on the extraordinary molecular-recognition skills of the chaperone HSP90, which allow this protein to interact selectively with hundreds of other proteins of diverse function.
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The authors are at The Institute of Cancer Research, London, UK, which has a commercial interest in HSP90 inhibitors. P.W. received research funding from Vernalis for the discovery of HSP90 inhibitors, and intellectual property from this programme was licensed to Vernalis and Novartis. P.W. was a founder of Chroma Therapeutics and is a scientific advisory board member for Astex Pharmaceuticals and Nextech Invest.
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Samant, R., Workman, P. Choose your protein partners. Nature 490, 351–352 (2012). https://doi.org/10.1038/490351a
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DOI: https://doi.org/10.1038/490351a