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Dicing defence in bacteria

A newly discovered variation in the process by which bacteria resist invasion by foreign nucleic acids provides an intriguing parallel between the defence mechanisms of the different domains of life. See Article p.602

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Figure 1: Flexibility in CRISPR processing systems.


  1. Jaskiewicz, L. & Filipowicz, W. Curr. Top. Microbiol. Immunol. 320, 77–97 (2008).

    CAS  PubMed  Google Scholar 

  2. Deltcheva, E. et al. Nature 471, 602–607 (2011).

    ADS  CAS  Article  Google Scholar 

  3. Karginov, F. V. & Hannon, G. J. Mol. Cell 37, 7–19 (2010).

    CAS  Article  Google Scholar 

  4. Marraffini, L. A. & Sontheimer, E. J. Nature Rev. Genet. 11, 181–190 (2010).

    CAS  Article  Google Scholar 

  5. Marraffini, L. A. & Sontheimer, E. J. Science 322, 1843–1845 (2008).

    ADS  CAS  Article  Google Scholar 

  6. Hale, C. R. et al. Cell 139, 945–956 (2009).

    CAS  Article  Google Scholar 

  7. Haft, D. H., Selengut, J., Mongodin, E. F. & Nelson, K. E. PLoS Comput. Biol. 1, e60 (2005).

    ADS  Article  Google Scholar 

  8. Brouns, S. J. J. et al. Science 321, 960–964 (2008).

    ADS  CAS  Article  Google Scholar 

  9. Carte, J., Wang, R., Li, H., Terns, R. M. & Terns, M. P. Genes Dev. 22, 3489–3496 (2008).

    CAS  Article  Google Scholar 

  10. Haurwitz, R. E. et al. Science 329, 1355–1358 (2010).

    ADS  CAS  Article  Google Scholar 

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Correspondence to Susan Gottesman.

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Gottesman, S. Dicing defence in bacteria. Nature 471, 588–589 (2011).

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