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Cell biology

Sensing tension

Measuring the tension forces at specific sites in living cells is technically challenging. Now, a fluorescent biosensor protein can be used to characterize dynamic local changes in tension in migrating cells.

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Figure 1: Tension biosensor.

References

  1. Mofrad, M. R. K. & Kamm, R. D. Cellular Mechanotransduction (Cambridge Univ. Press, 2009).

    Book  Google Scholar 

  2. Vogel, V. & Sheetz, M. Nature Rev. Mol. Cell Biol. 7, 265–275 (2006).

    Article  CAS  Google Scholar 

  3. Orr, A. W., Helmke, B. P., Blackman, B. R. & Schwartz, M. A. Dev. Cell 10, 11–20 (2006).

    Article  CAS  Google Scholar 

  4. Ridley, A. J. et al. Science 302, 1704–1709 (2003).

    Article  ADS  CAS  Google Scholar 

  5. Grashoff, C. et al. Nature 466, 263–266 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Klotzsch, E. et al. Proc. Natl Acad. Sci. USA 106, 18267–18272 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Meng, F., Suchyna, T. M. & Sachs, F. FEBS J. 275, 3072–3087 (2008).

    Article  CAS  Google Scholar 

  8. Iwai, S. & Uyeda, T. Q. P. Proc. Natl Acad. Sci. USA 105, 16882–16887 (2008).

    Article  ADS  CAS  Google Scholar 

  9. del Rio, A. et al. Science 323, 638–641 (2009).

    Article  ADS  CAS  Google Scholar 

  10. Sawada, Y. et al. Cell 127, 1015–1026 (2006).

    Article  CAS  Google Scholar 

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Doyle, A., Yamada, K. Sensing tension. Nature 466, 192–193 (2010). https://doi.org/10.1038/466192a

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