Sir
Your News story 'Long-held theory is in danger of losing its nerve'1 described a published criticism of work we published 25 to 26 years ago and our reply (references are in ref. 1). In it, you quote unnamed experts who maintain that much of the published work that might be consistent with the one-vesicle hypothesis addressed in the News story has problems.
Recognizing that this News story was not a scientific article, we think it is important to clarify that our work, and that hypothesis, have been discussed extensively in the literature and in public forums2, including the exchange of data and analytical tools with another laboratory (see ref. 3). Data consistent with it have also been published quite recently4. We all now recognize that neurotransmitter chemical release at synapses is heterogeneous and may function differently in different biological systems.
References
Nature 449, 124–125 (2007).
Central Synapses: Quantal Mechanisms and Plasticity (eds. Faber, D. S. et al.) HFSP, Strasbourg (1998).
Redman, S. Physiol. Rev. 70, 165–198 (1990).
Silver, R. A. et al. Science 302, 1981–1984 (2003).
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Korn, H., Faber, D., Triller, A. et al. One-vesicle hypothesis has been extensively discussed. Nature 449, 781 (2007). https://doi.org/10.1038/449781d
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DOI: https://doi.org/10.1038/449781d
