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Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor

Molecular Psychiatry volume 5, pages 548–551 (2000)Cite this article

Abstract

A recent study has suggested a possible association of a polymorphism near the dopamine D5 receptor gene (DRD5) and attention-deficit hyperactivity disorder.1 The polymorphism studied was a (CA)n repeat located in the cosmid containing the D5 receptor gene2 and the allele that was reported to be associated with attention-deficit hyperactivity disorder (ADHD) was the 148-bp allele. In this study we sought to replicate this finding by testing for biased transmission of the alleles at this same polymorphism in a sample of 92 families with an ADHD proband. We did not observe significant evidence for biased transmission of the 148-bp allele, however we did observe biased transmission of two other alleles, the 136-bp allele and the 146-bp allele. For these two alleles the bias was for these two alleles not to be transmitted to the ADHD children. The number of informative transmissions for these two alleles was small, therefore it would be premature to make any conclusions from our study concerning the role of DRD5 in ADHD.

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Acknowledgements

This work was supported by grants from The Hospital for Sick Children Psychiatric Endowment Fund, The National Alliance for Research in Schizophrenia and Depression (CLB and JLK), National Health Research Development Program of Health Canada (6606-5612-401, RS) and the Medical Research Council of Canada (MT14336 and PG11121).

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Authors and Affiliations

  1. Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada

    C L Barr, K G Wigg, Y Feng & G Zai

  2. Department of Psychiatry, The Hospital for Sick Children and the University of Toronto, Toronto, Canada

    C L Barr, R Schachar & R Tannock

  3. Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Canada

    M Malone & W Roberts

  4. Clarke Division, Neurogenetics Section, The Centre for Addictions and Mental Health, University of Toronto, Toronto, Canada

    J L Kennedy

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  1. C L Barr
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  2. K G Wigg
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  3. Y Feng
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  4. G Zai
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  5. M Malone
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  6. W Roberts
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  7. R Schachar
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  8. R Tannock
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  9. J L Kennedy
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Correspondence to C L Barr.

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Barr, C., Wigg, K., Feng, Y. et al. Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor. Mol Psychiatry 5, 548–551 (2000). https://doi.org/10.1038/sj.mp.4000777

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  • DOI: https://doi.org/10.1038/sj.mp.4000777

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