Hox gene expression in teleost fins and the origin of vertebrate digits

Abstract

HOX genes are essential for growth and patterning of the tetrapod limb skeleton1–5. Mice mutant for the Hoxd-13gene have an important delay in morphogenesis owing to reduced proliferation2. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of morphological variation during the evolution of tetrapod limbs2,6. Pectoral and pelvic fins are homologous to fore- and hind-limbs, respectively. To compare the relative importance of Hox genes during fin versus limb morphogenesis, we cloned zebrafish (Danio rerio) HoxD and HoxA complex genes and analysed their expression during fin development. The results suggest a scheme for the fin–limb transition in which the distal autopods (digits) are neomorphic structures produced by unequal proliferation of the posterior part of an ancestral appendix.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Dollé, P., Izpsiúa-Belmonte, J.-C., Falkenstein, H., Renucci, A. & DuBoule, D. Nature 342, 767–772 (1989).

    ADS  Article  Google Scholar 

  2. 2

    Dollé, P. et al. Cell 75, 431–441 (1993).

    Article  Google Scholar 

  3. 3

    Davis, A. P. & Capecchi, M. R. Development 120, 2187–2199 (1994).

    CAS  Google Scholar 

  4. 4

    Small, K. M. & Potter, S. S. Genes Dev. 7, 2318–2328 (1993).

    CAS  Article  Google Scholar 

  5. 5

    Favier, B., Le Meur, M., Chambon, P. & Dollé, P. Proc. natn. Acad. Sci. U.S.A. 92, 310–314 (1995).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Duboule, D. Development (suppl.), 135–142 (1994).

  7. 7

    Hinchliffe, J. R. & Johnson, D. R. The Development of the Vertebrate Limb (Clarendon, Oxford, 1980).

    Google Scholar 

  8. 8

    Shubin, N. H. & Alberch, P. in Evolutionary Biology (eds Hecht, M. K., Wallace, B. & Prance, G. I.) 319 (Plenum, New York, 1986).

    Google Scholar 

  9. 9

    Tabin, C. J. Cell, 66, 199–217 (1991).

    CAS  Article  Google Scholar 

  10. 10

    Tickle, C. Development (suppl.) 1, 113–121 (1991).

    CAS  Google Scholar 

  11. 11

    Summerbell, D., Lewis, J. H. & Wolpert, L. C. J. Nature 244, 492–496 (1973).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Izpisua-Belmonte, J.-C. & Duboule, D. Devl Biol. 152, 26–36 (1992).

    CAS  Article  Google Scholar 

  13. 13

    Yokouchi, Y., Sasaki, H. & Kunoiwa, A. Nature 353, 443–445 (1991).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Haack, H. & Gruss, P. Devl Biol. 157, 410–422 (1993).

    CAS  Article  Google Scholar 

  15. 15

    Coates, M. I. Development (suppl.), 169–180 (1994).

  16. 16

    Ahlberg, P. E. & Milner, A. R. Nature 368, 507–512 (1994).

    ADS  Article  Google Scholar 

  17. 17

    Dane, P. J. & Tucker, J. B. J. Embryol. exp. Morph. 87, 145–161 (1985).

    CAS  PubMed  Google Scholar 

  18. 18

    Géraudie, J. Acta. zool. Stockh. 59, 85–96.

  19. 19

    Potthoff, T. & Tellock, J. A. Bull. mar. Sci. 52, 669–716 (1993).

    Google Scholar 

  20. 20

    Krauss, S., Concordet, J. P. & Ingham, P. Cell 75, 1431–1444 (1993).

    CAS  Article  Google Scholar 

  21. 21

    Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. J. Cell 75, 1401–1416 (1993).

    CAS  Article  Google Scholar 

  22. 22

    Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. & Tabin, C. J. Cell 79, 993–1003 (1994).

    CAS  Article  Google Scholar 

  23. 23

    Thorogood, P. in Developmental Patterning of the Vertebrate Limb (eds Hinchliffe, J. R., Huerle J. M. & Summerbell, D.) 347–354 (Plenum, New York, 1991).

    Google Scholar 

  24. 24

    Duboule, D. Science 266, 575–576 (1994).

    ADS  CAS  Article  Google Scholar 

  25. 25

    Niswander, L., Jeffrey, S., Martin, G. R. & Tickle, C. Nature 371, 609–612 (1994).

    ADS  CAS  Article  Google Scholar 

  26. 26

    Coates, M. in Developmental Patterning of the Vertebrate Limb (eds Hinchliffe, J. R., Huerle, J. M. & Summerbell, D.) 328–338 (Plenum, New York, 1991).

    Google Scholar 

  27. 27

    Holmgreen, N. Acta zool. Stockh. 33, 1–115 (1952).

    Article  Google Scholar 

  28. 28

    Shubin, N. in Evolutionary Biology (eds Hecht, M. K., Macintyre, R. J. & Clegg, M. T.) 39–86 (Plenum, New York, 1995).

    Google Scholar 

  29. 29

    Streisinger, G., Singer, F., Walker, C., Knauber, D. & Dower, N. Genetics 112, 311–319 (1981).

    Google Scholar 

  30. 30

    Strähle, U. & Ingham, P. W. Zebrafish Sci. Monitor 2, 5–7 (1993).

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sordino, P., van der Hoeven, F. & Duboule, D. Hox gene expression in teleost fins and the origin of vertebrate digits. Nature 375, 678–681 (1995). https://doi.org/10.1038/375678a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing