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Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM

Nature volume 372, pages 777–779 (1994)Cite this article

Abstract

SYNAPTIC membranes express cell adhesion molecules1. Here we investigate the role of the neural cell adhesion molecules L1 and NCAM in hippocampal long-term potentiation (LTP), a sustained-use-dependent increase in synaptic efficacy that has been impli-cated in learning and memory2. L1 and NCAM mediate cell inter-actions during neural development3 and are strongly expressed in the hippocampus4,5. They cooperate to strengthen L1-dependent cell adhesion6–9 and are coupled to second messenger pathways10–12. We show that LTP in CA1 neurons of rat hippo-campal slices was reduced by application of various L1 and NCAM antibodies, recombinant LI fragments, and upon dissociation of the L1/NCAM complex through oligomannosidic carbohydrates and NCAM peptides. Neither the activation of NMDA (N-methyl-D-aspartate) receptors nor the maintenance of LTP was affected. These results suggest that L1 and NCAM modulate the develop-ment or the stabilization of LTP13.

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Authors and Affiliations

  1. Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland

    Andreas Lüthi & Jean-Paul Laurent

  2. Department of Pharmacology, Centre Medical Universitaire, CH-1211, Geneve, 4, Switzerland

    Alexander Figurovt & Dominique Mullert

  3. Department of Neurobiology, Swiss Federal Institute of Technology, HÖnggerberg, CH-8093, Zurich, Switzerland

    Melitta Schachnert

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Lüthi, A., Laurent, JP., Figurovt, A. et al. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372, 777–779 (1994). https://doi.org/10.1038/372777a0

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