Abstract
THIS PAPER HAS BEEN RETRACTED; see retraction.
A diversity of high-affinity Oligosaccharide ligands are identified for NKR-P1, a membrane protein on natural killer (NK) cells which contains an extracellular Ca2+-dependent lectin domain. Interactions of such oligosaccharides on the target cell surface with NKR-P1 on the killer cell surface are crucial both for target cell recognition and for delivery of stimulatory or inhibitory signals linked to the NK cytolytic machinery. NK-resistant tumour cells are rendered susceptible by preincubation with liposomes expressing NKR-P1 ligands, suggesting that purging of tumour or virally infected cells in vivo may be a therapeutic possibility.
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Bezouška, K., Yuen, CT., O'Brien, J. et al. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature 372, 150–157 (1994). https://doi.org/10.1038/372150a0
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DOI: https://doi.org/10.1038/372150a0
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