Article | Published:

The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation

Nature volume 362, pages 423427 (01 April 1993) | Download Citation

Subjects

Abstract

The mossy fibre pathway in the hippocampus uses glutamate as a neurotransmitter, but also contains the opioid peptide dynorphin. Synaptic release of dynorphin causes a presynaptic inhibition of neighbouring mossy fibres and inhibits the induction and expression of mossy fibre long-term potentiation. These findings demonstrate a physiological role for a neuropeptide in the central nervous system, provide a functional basis for the coexistence of a neuropeptide with classic neurotransmitters and demonstrate the very different roles played by these two classes of signalling molecules.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Neuron 7, 867–879 (1991).

  2. 2.

    & J. Physiol. 327, 219–246 (1982).

  3. 3.

    & Trends Neurosci. 6, 320–325 (1983).

  4. 4.

    & Trends Neurosci. 6, 325–333 (1983).

  5. 5.

    et al. Nature 301, 517–520 (1983).

  6. 6.

    & Nature 244, 442–443 (1973).

  7. 7.

    , & J. comp. Neurol. 198, 335–350 (1981).

  8. 8.

    , , , & Proc. natn. Acad. Sci. U.S.A. 80, 589–593 (1983).

  9. 9.

    , , , & J. comp. Neurol. 255, 497–510 (1987).

  10. 10.

    , & J. Neurochem. 57, 333–343 (1991).

  11. 11.

    et al. Brain Res. Bull. 21, 343–351 (1988).

  12. 12.

    , , & Neurosci. Lett. 63, 190–194 (1986).

  13. 13.

    & J. pharmac. Exp. Ther. 252, 1361–1369 (1990).

  14. 14.

    Trends pharmacol. Sci. 8, 456–459 (1987).

  15. 15.

    , & Science 215, 413–415 (1982).

  16. 16.

    , , & J. Pharmac. exp. Ther. 246, 255–258 (1988).

  17. 17.

    , , , & Proc. natn. Acad. Sci. U.S.A. 74, 2584–2588 (1977).

  18. 18.

    , , & Science 205, 415–417 (1979).

  19. 19.

    , & J. Pharmac. exp. Ther. 244, 564–570 (1988).

  20. 20.

    & Synapse 8, 237–248 (1991).

  21. 21.

    & Br. J. Pharmac. 77, 461–469 (1982).

  22. 22.

    et al. Proc. natn. Acad. Sci. U.S.A. 80, 5871–5874 (1983).

  23. 23.

    , , & J. Pharmac. exp. Ther. 254, 412–419 (1990).

  24. 24.

    , , , & Proc. natn. Acad. Sci. U.S.A. 85, 4061–4065 (1988).

  25. 25.

    A. Rev. Neurosci. 12, 13–31 (1989).

  26. 26.

    & J. Physiol. 195, 481–492 (1968).

  27. 27.

    & J. Physiol. 196, 593–604 (1968).

  28. 28.

    , & J. Physiol. 299, 409–424 (1980).

  29. 29.

    , , & Neuroscience 20, 231–239 (1987).

  30. 30.

    & Brain Res. 548, 242–247 (1991).

  31. 31.

    , & J. Brain Res. 574, 138–146 (1992).

  32. 32.

    , , , & Neuroscience 41, 449–458 (1991).

  33. 33.

    Brain Res. 583, 237–246 (1992).

  34. 34.

    , & J. Neurosci. 12, 132–141 (1992).

  35. 35.

    & Neuroscience 35, 265–271 (1990).

  36. 36.

    & Neurosci. Lett. 138, 193–197 (1992).

  37. 37.

    Neuropeptides 4, 45–50 (1983).

  38. 38.

    & Science 248, 1619–1624 (1990).

  39. 39.

    , & Synapse 5, 333–335 (1990).

  40. 40.

    & Proc. natn. Acad. Sci. U.S.A. 84, 5469–5473 (1987).

  41. 41.

    Nature 340, 153–156 (1989).

  42. 42.

    , , , & Eur. J. Pharmac. 174, 63–70 (1989).

  43. 43.

    , , & Neuropharmacology 29, 439–444 (1990).

  44. 44.

    , & Neurosci. Lett. 91, 84–88 (1988).

  45. 45.

    in Opioids in the Hippocampus (eds McGinty. J. F. & Friedman, D. P.) 118–132 (NIDA Res. Monograph, 1988).

  46. 46.

    & Synapse 7, 151–168 (1991).

  47. 47.

    & Brain Res. 310, 384–387 (1984).

  48. 48.

    Cold Spring Harb. Symp. quant. Biol. 55, 995–1006 (1990).

  49. 49.

    & in Transmitter Amino Acid Receptors: Structures, Transduction and Models for Drug Development Vol. 6 (Barnard, E. A. & Costa. E.) 415–422 (Thieme Medical, New York, 1991).

Download references

Author information

Affiliations

  1. Neuroscience Graduate Program, University of California, San Francisco, California 94143–0450, USA

    • Marc G Weisskopf
  2. The Departments of Pharmacology and Physiology, University of California, San Francisco, California 94143–0450, USA

    • Robert A Zalutsky
  3. To whom correspondence should be addressed

    • Roger A Nicoll

Authors

  1. Search for Marc G Weisskopf in:

  2. Search for Robert A Zalutsky in:

  3. Search for Roger A Nicoll in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/362423a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.