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Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes

Nature volume 356, pages 66–68 (1992)Cite this article

Abstract

HUMAN papillomaviruses associated with cutaneous1 and ano-genital2 cancers induce intraepithelial precursor lesions which may regress spontaneously or progress into invasive carcinomas3,4. Cell-mediated immune responses are probably involved in regression of precancerous lesions1,5–8 and the polymorphism of the genes responsible may thus have a key role in the variability of the host response. Skin warts and cancers induced in rabbits by Shope papillomavirus9–12 provide a model to test this hypothesis. We analysed a restriction-fragment-length polymorphism of major histocompatibility complex class I and class II genes13,14 and T-cell receptor β-chain genes15 in infected domestic rabbits. We found a strong linkage between wart regression and a DRαEcoRI fragment, and an increased relative risk of malignant transformation associated with a DQα PvuII fragment. This indicates a genetic control of wart evolution, involving genes in the class II region of the major histocompatibility complex.

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References

  1. Orth, G. in The papovaviridae: The papillomaviruses (eds Salzman, N. P. & Howley, P. M.) 199–243 (Plenum, New York, 1987).

    Book  Google Scholar 

  2. zur Hausen, H. Cancer Res. 49, 4677–4681 (1989).

    CAS  PubMed  Google Scholar 

  3. Carmichael, J. A. & Maskens, P. D. Am. J. Obstet. Gynec. 160, 916–918 (1989).

    Article  CAS  Google Scholar 

  4. Nasiell, K., Roger, V. & Nasiell, M. Obstet. Gynec. 67, 665–669 (1986).

    Article  CAS  Google Scholar 

  5. Majewski, S. et al. J. Am. Acad. Derm. 22, 423–427 (1990).

    Article  CAS  Google Scholar 

  6. Cooper, K. D., Androphy, E. J., Lowy, D. & Katz, S. I. J. invest Derm. 94, 769–776 (1990).

    Article  CAS  Google Scholar 

  7. Malejczyk, J. et al. Cell. Immun. 136, 155–164 (1991).

    Article  CAS  Google Scholar 

  8. Chen, L., Thomas, E. K., Hu, S.-L., Hellström, I. & Hellström, E. Proc. natn. Acad. Sci. U.S.A. 88, 110–114 (1991).

    Article  ADS  CAS  Google Scholar 

  9. Shope, R. E. J. exp. Med. 58, 607–624 (1933).

    Article  CAS  Google Scholar 

  10. Beard, J. W. & Rous, P. J. exp. Med. 60, 723–740 (1934).

    Article  CAS  Google Scholar 

  11. Rous, P. & Beard, J. W. J. exp. Med. 62, 523–548 (1935).

    Article  CAS  Google Scholar 

  12. Kreider, J. W. & Bartlett, G. L. Adv. Cancer Res. 35, 81–110 (1981).

    Article  CAS  Google Scholar 

  13. Marche, P. N. et al. Immunogenetics 29, 273–276 (1989).

    Article  CAS  Google Scholar 

  14. Sittisombut, N., Tisssot, R. G. & Knight, K. L. J. Immunogenet. 16, 63–75 (1989).

    Article  CAS  Google Scholar 

  15. Marche, P. N. & Kindt, T. J. J. Immunol. 137, 1729–1734 (1986).

    CAS  PubMed  Google Scholar 

  16. Bourker, G. F., Daly, L. E. & McGilvray, J. Interpretation and Uses of Medical Statistics 3rd edn (Blackwell, Oxford, 1985).

    Google Scholar 

  17. Payami, H. et al. Am. J. hum. Genet. 45, 541–546, 1989.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Meneguzzi, G., Cerni, C., Kieny, M.-P. & Lathe, R. Virology 181, 62–69 (1991).

    Article  CAS  Google Scholar 

  19. Georges, E., Croissant, O., Bonneaud, N & Orth, G. J. Virol. 51, 530–538 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Nasseri, M. & Wettstein, F. O. J. Virol. 51, 706–712 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Tagami, H., Aiba, S. & Rokugo, M. Clin. Derm. 3(4), 170–178 (1985).

    Article  CAS  Google Scholar 

  22. Kappes, D. & Strominger, J. L. A. Rev. Biochem. 57, 991–1028 (1988).

    Article  CAS  Google Scholar 

  23. Wank, R. & Thomssen, C. Nature 352, 723–725, 1991.

    Article  ADS  CAS  Google Scholar 

  24. Beutler, B. J. invest. Derm. 95, 81s–84s (1990).

    Article  CAS  Google Scholar 

  25. Yoshikawa, T. & Streilein, J. W. Immunogenetics 32, 398–405, 1990.

    Article  CAS  Google Scholar 

  26. Favre, M., Breitburd, F., Croissant, O. & Orth, G. J. Virol. 15, 1239–1247 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Unité des Papillomavirus, INSERM U190, CNRS URA 359, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, Cedex 15, France

    Ricaï Man, Françoise Breitburd, Patrice N. Marche & Gérard Orth

  2. Unité d'lmmunochimie Analytique, CNRS URA 359, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris, Cedex 15, France

    Patrice N. Marche

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  1. Ricaï Man
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  2. Françoise Breitburd
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  4. Gérard Orth
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Man, R., Breitburd, F., Marche, P. et al. Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes. Nature 356, 66–68 (1992). https://doi.org/10.1038/356066a0

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