A renaissance for the tumor immunosurveillance hypothesis. Lanier, L. L. Nature Medicine November (2001) Nature Medicine This News and Views article discusses the recent observation that a subset of T cells that express the γ/δ-T-cell receptor protect against skin cancer. As little was previously known about this population, this study sheds new light on the function of these lymphocytes and their role in tumour surveillance. See also the Highlight on page 95 of this issue.

MEN and SIN: what's the difference? Bardin, A. J. & Amon, A. Nature Reviews Molecular Cell Biology November (2001) Nature Reviews Molecular Cell Biology

Transmembrane cross-talk between the extracellular matrix and the cytoskeleton. Geiger, B., Bershadsky, A., Pankov, R. & Yamada, K. M. Nature Reviews Molecular Cell Biology November (2001) Nature Reviews Molecular Cell Biology

Cancer virotherapy. Vile, R. Nature Biotechnology November (2001) Nature Biotechnology Replicating adenoviruses selectively destroy tumour cells. This News and Views article discusses the paper by Ramachandra et al ., published in the same issue, reporting a new oncolytic adenovirus that targets p53-negative tumour cells.

Size matters to a telomere. Bonetta, L. Nature Medicine November (2001) Nature Medicine This short News and Views article discusses the recent finding of how cells sense the length of their telomeres.

The ETS-domain transcription factor family. Sharrocks, A. D. Nature Reviews Molecular Cell Biology November (2001) Nature Reviews Molecular Cell Biology The ETS-domain family of transcription factors is involved in a variety of processes, from haematopoietic development in mammals to eye-cell fate in fruit flies, and dysregulation of ETS family members occurs in a range of different cancer types. This review discusses how the specific action of each ETS family member is achieved through co-regulatory partners.

A family outing: small GTPases cyclin' through G1. Coleman, M. L. & Marshall, C. J. Nature Cell Biology November (2001) Nature Cell Biology This News and Views article discusses the paper by Assoian et al ., published in the same issue, reporting that the signal-transduction pathways of the small G proteins Ras, Rho and Rac interact to regulate expression of cyclin D1. These findings illuminate a new link between growth-factor activation and cell proliferation.

Organelle-specific initiation of cell death pathways. Ferri, K. F. & Kroemer, G. Nature Cell Biology November (2001) Nature Cell Biology Mitochondrial membrane permeabilization and caspase activation are known to trigger apoptosis, but recent evidence indicates that other organelles, such as the endoplasmic reticulum, lysosomes and the Golgi apparatus, also sense damage and signal apoptosis. This review discusses the various mechanisms by which these organelles sense cellular stress and respond, and how these activities lead to cell death.