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Development

DNA methylation in Drosophila melanogaster

Nature volume 408, pages 538540 (30 November 2000) | Download Citation

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Abstract

Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception1,2,3,4, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well5,6,7,9. Here we show that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.

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Affiliations

  1. *Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA

    • Frank Lyko
    •  & Rudolf Jaenisch
  2. †John Hughes Bennett Laboratory, Department of Oncology, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK

    • Bernard H. Ramsahoye
  3. ‡Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Rudolf Jaenisch

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Correspondence to Rudolf Jaenisch.

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DOI

https://doi.org/10.1038/35046205

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